The most amount of US Senate seats the Democrats will have after 2022 is 55.

[nkpolitics1212]

37)HI(Schatz-D)
38)NY(Schumer-D)
39)CA(Padilla-D)
40)MD(Van Hollen-D)
41)CT(Blumenthal-D)
42)VT(Leahy-D)
43)OR(Wyden-D)
44)WA(Murray-D)
45)IL(Duckworth-D)
46)CO(Bennet-D)
47)NV(Cortez Masto-D)
48)AZ(Kelly-D)
49)PA(Fetterman-D)
50)GA(Warnock-D)
51)WI(Godlewski-D)
52)NH(Hassan-D)
53)NC(Beasley-D)
54)OH(Ryan-D)
55)FL(Demings-D)

Could Democrats win-
56)AK(Gross-D vs Tshibaka-R)Murkowski-R finishes in 3rd place in the blanket primary.
57)IA(Axne-D or Finkenaur-D) vs either of the Grassley-R.
58)KY(Booker-D vs RuPaul-R)
59)MO(Sifton-D vs Grietens-R)
60)IN(McDermott-D vs Young-R)