Iowa Resident Dies of Rare West African Lassa Fever

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The current risk of Lassa virus transmission in the US is "incredibly low," Iowa's medical director says.
(Image: CS Goldsmith, P. Rollin, M. Bowen/CDC)

A resident of eastern Iowa who had recently traveled to West Africa died after catching Lassa fever. The virus, which is in the same viral hemorrhagic fever category as Ebola, is rarely seen in the US.

The Iowa Department of Health and Human Services announced the death but did not release the person’s name and disclosed few details about them. Preliminary tests were presumptively positive for the virus, and the US CDC is working to confirm the diagnosis.


(Map: worldatlas.com)

The department said the person was middle-aged and had traveled to West Africa, where it is believed they contracted the virus. The current risk of transmission in the US is “incredibly low,” according to Iowa State Medical Director Dr. Robert Kruse.

Each year, about 100,000 to 300,000 people become infected with Lassa fever in West Africa, where the disease is endemic, according to the Center for Infectious Disease Research & Policy at the University of Minnesota. Since 1969, there have been only eight known cases in the US, all of them travel-related.

It’s even rarer for someone to die from Lassa fever. The disease has an overall fatality rate of just 1%, according to the World Health Organization. In severe cases, the patient may have bleeding; difficulty breathing; pain in the chest, back and abdomen; and vomiting. Someone with milder symptoms may develop a slight fever, feel tired or have a headache. Most people who are infected with Lassa virus have no symptoms at all.

Lassa fever can spread between humans but not through casual contact. Typically, the virus spreads only when someone comes into contact with an infected person’s bodily fluids.

Lassa fever most commonly spreads through the multimammate rat in West Africa. People can get sick after touching objects contaminated with rat feces or urine, or after eating food that’s been contaminated. Some people also get sick after eating the rats themselves, according to the CDC.


Natal multimammate rat. (Photo: www.iNaturalist.org)

Prompt treatment is considered key for Lassa fever. Ribavirin, a broad-spectrum antiviral that works well against RNA viruses and is also used to treat hepatitis C, is the primary treatment.

The Iowa Department of Health is investigating and monitoring the situation in conjunction with the CDC and local public health partners. The agencies are trying to determine who may have had close contact with the patient, who had been treated in isolation at the University of Iowa Health Care Medical Center.

The CDC says the patient was not sick while traveling, so the risk to other airline passengers is extremely low.

Sources:

https://hhs.iowa.gov/news-release/2024-10-28/state-and-hospital-officials-follow-federal-guidance-after-lassa-fever-death

https://www.cdc.gov/lassa-fever/about/index.html?utm_medium=email&utm_source=govdelivery

https://www.cnn.com/2024/10/28/health/lassa-fever-case-iowa/index.html

[louis-t]

1. Anyone that remembers the soap opera General Hospital in the '70s

knows about Lassa fever. A kid went to Africa and came back as a carrier. The breakout lasted for several weeks on the show. The hospital was trying to figure out who the carrier was. All the while the kid kept saying "On my trip to Africa, blah, blah..." Nobody paid attention to him. One of the few times I ever watched a soap for more than one episode. I must have been really bored.

[C0RI0LANUS]

2. Ah, the ladykiller and handsome Rick Springfield used to grace "General Hospital."

Please don't tell my ever-loving wife I wrote that.