Scientists Uncover a Hidden Brain Plumbing System That Restores Memory

[erronis]

https://scitechdaily.com/scientists-uncover-a-hidden-brain-plumbing-system-that-restores-memory/


Aging compromises the lymphatic vessels (green) in tissue called the meninges (blue) surrounding the brain, disabling waste drainage from the brain and impacting cognitive function. Researchers at WashU Medicine boosted lymphatic vessel integrity (bottom) in old mice and found improvements in their memory compared with old mice without rejuvenated lymphatic vessels (top). Credit: Kyungdeok Kim

Aging brains may struggle to clear out waste, contributing to memory loss and diseases like Alzheimer’s.

But researchers have now found that improving the brain’s waste-draining vessels in old mice actually boosted their memory. Rather than targeting the brain directly, which is tricky due to the blood-brain barrier, this study focused on the surrounding lymphatic vessels. Not only did this lead to cognitive improvements, but it also reduced harmful brain inflammation.

Aging and Brain Waste Buildup

As the body ages, the brain becomes less effective at clearing out waste, a problem researchers believe may contribute to neurodegenerative diseases like Alzheimer’s and Parkinson’s. Now, scientists at Washington University School of Medicine in St. Louis have identified a way to address this issue by focusing on a network of vessels that help drain waste from the brain. Their findings show that rejuvenating these vessels can improve memory in older mice.

Published on March 21 in the journal Cell, the study offers a potential new approach to treating age-related cognitive decline, one that avoids the challenge of getting medications past the brain’s protective barrier.

“The physical blood-brain barrier hinders the efficacy of therapies for neurological disorders,” said Jonathan Kipnis, PhD, the Alan A. and Edith L. Wolff Distinguished Professor of Pathology & Immunology and a BJC Investigator at WashU Medicine. “By targeting a network of vessels outside of the brain that is critical for brain health, we see cognitive improvements in mice, opening a window to develop more powerful therapies to prevent or delay cognitive decline.”

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[Nigrum Cattus]

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[erronis]

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