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RandySF

(70,944 posts)
Fri Jan 27, 2023, 04:03 PM Jan 2023

Common antidepressants may blunt both pain and enjoyment

“Emotional blunting is a common side effect of SSRI antidepressants. In a way, this may be in part how they work—they take away some of the emotional pain that people who experience depression feel, but, unfortunately, it seems that they also take away some of the enjoyment,” said Professor Barbara Sahakian, a co-author and professor of psychology the University of Cambridge, in a statement. “From our study, we can now see that this is because they become less sensitive to rewards, which provide important feedback.”

SSRIs target serotonin, a chemical in the brain called the “pleasure chemical” or the “happiness molecule” that carries messages between nerve cells. According to the National Health Service (NHS), more than 8.3 million patients in England received an antidepressant during 2021 and 2022. In the United States, prescriptions for anti-anxiety and antidepressants increased by an estimated 21 percent following the COVID-19 pandemic.

A team led by researchers at the University of Cambridge and the University of Copenhagen looked into the long term clinical use of SSRIs. They recruited 66 healthy volunteers and gave 32 of them an SSRI called escitalopram and the other 34 took a placebo. According to the team, this drug is known to be one of the best-tolerated antidepressants available on the market and the study participants took them over 21 days.

The participants completed self-reported questionnaires and were given a series of tests that assessed learning, inhibition, executive function, reinforcement behavior, and decision-making.



https://www.popsci.com/health/antidepressants-emotional-blunting/

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Common antidepressants may blunt both pain and enjoyment (Original Post) RandySF Jan 2023 OP
A friend took Prozac and said it decreased her enjoyment of sex. keithbvadu2 Jan 2023 #1
I've experienced that with a few meds. hunter Feb 2023 #3
I take Zoloft 100 mg daily. John1956PA Jan 2023 #2
I feel the same way. I am alive because of antidepressants TexasBushwhacker May 2023 #4

keithbvadu2

(40,321 posts)
1. A friend took Prozac and said it decreased her enjoyment of sex.
Fri Jan 27, 2023, 04:24 PM
Jan 2023

A friend took Prozac and said it decreased her enjoyment of sex.

Said she did not care much at all about it.

She stopped that medication.

hunter

(39,004 posts)
3. I've experienced that with a few meds.
Wed Feb 1, 2023, 11:32 PM
Feb 2023

I've also quit meds abruptly with worse consequences.

There are some psych meds you should never quit cold turkey.

I'm an idiot who learned that the hard way.

John1956PA

(3,411 posts)
2. I take Zoloft 100 mg daily.
Fri Jan 27, 2023, 04:58 PM
Jan 2023

It is a serotonin reuptake inhibitor. For me, the benefits outweigh any side effects.

TexasBushwhacker

(20,711 posts)
4. I feel the same way. I am alive because of antidepressants
Tue May 30, 2023, 10:39 PM
May 2023

Over the 45 years since my first episode of major depression, I have taken just about every kind of antidepressant, as well as combinations and occasionally low doses of antipsychotics. Every time I've tapered off, with my doctor's guidance, I've ended up in the hospital. It's just my row to hoe. My dad was bipolar.

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