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In reply to the discussion: Why Does Coffee Make Me Poop? [View all]

hlthe2b

(106,585 posts)
17. Actually there is direct brain impact on gastric-colic reflex-- including circadian rhythms--
Fri Dec 3, 2021, 07:57 AM
Dec 2021

for which a central clock or “pacemaker” is located in the hypothalamic suprachiasmatic nucleus (SCN), which receives photic input via the retinohypothalamic tract. While peripheral tissues have some effect even with damage to these hypothalamic centers-- such that timed feedings can still induce gastric motility and thus some "regularity," there are impacts (and thus the issues frequently seen with gastric motility among shift workers).

The brain has influence on everything quite frankly. Thus, stimulants should not be expected to be unrelated to such signals. It is not merely local innervation detecting a "filling effect," though that surely has some impact as well.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950682/


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