Just a couple of thoughts for now.
Hybrid seeds - yes, they may be different, but often still worth doing. The tomato folks know (I guess, I'm just casually into this whole saving/breeding business) that you can "convert" a hybrid into an OP line over a few years if you do it right. I've saved seeds from Fourth of July and Sungold and was very satisfied with the offspring, didn't really see all that much difference, although with several generations Sungold tomatoes get a lot smaller and paler, but flavor stays fine.
Thought # 2 -- don't do what I did just a few weeks ago, which was harvest a bunch of mature seed heads of artichokes and cardoon, then put them on a cookie sheet near a heat register in an unused room and walk away a while and forget them. They fluffed out like the giant thistles they are, and I ended up having to clean up silk parachutes all over the place -- when I went in there, the air currents made them fly. Neat to see, but messy. In the future, I'll dry them in a mesh bag so they can't escape.