Culture Shift - Asimov Press

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We tend to think of fermented foods as something humans invented and then chose to eat. But the evidence shows the opposite: fermented foods shaped human biology.
Asimov Press
Mar 20, 2026

By Rachel Dutton

The human immune system is, in one sense, a detection mechanism. It has evolved, over millions of years, to scan the body for molecular signals that tell it whether to attack or stand down. Most of these signals come from pathogens, damaged cells, or the body’s own hormones. But in 2019, a lab in Germany published a finding that pointed to a much stranger source: one of the signals sensed by the immune system is found in sauerkraut.

When people eat sauerkraut, a molecule called phenyllactic acid (D-PLA) — found in fermented foods — enters their bloodstream and activates a receptor, known as HCA3, on immune cells, triggering an anti-inflammatory response. In addition to lactic acid, phenyllactic acid is one of many compounds produced by lactic acid bacteria during the fermentation of sauerkraut and related fermented foods. Prior to this study, other molecules had been found to bind HCA3, but D-PLA was a hundredfold more potent than any of them.

This discovery advances our understanding of how fermented foods can reduce inflammation and positively affect human health. But more striking is what it suggests about hominid physiology. Although HCA3 is part of a larger family of receptors broadly conserved across eukaryotes, HCA3 is only present in humans and other great apes like chimpanzees and gorillas — and not even in other mammals. It is a recent addition to the genome, appearing only a few million years ago. Its existence seems to suggest that our immune system evolved to recognize the microbial metabolites from fermented foods.

We tend to think of fermented foods as something humans invented and then chose to eat. But, increasingly, scientific evidence suggests the causality runs the other way. Fermented foods appear to have helped shape human biology itself, and our bodies may have been built, in part, to expect them. The case for this runs from changes in hominid gut anatomy millions of years ago to the HCA3 receptor, to a growing body of research linking fermented food consumption to immune function and gut health. And it raises an uncomfortable question about what happened when the Western food system, in the name of safety and efficiency, quietly removed these foods from our diets in the nineteenth and twentieth centuries.

Continued
https://open.substack.com/pub/cell/p/culture-shift